The microbiological transformation of the diterpenes dehydroabietanol and teideadiol by Mucor plumbeus |
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| Authors: | Fraga Braulio M Hernández Melchor G Artega Jose M Suárez Sergio |
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| Institution: | Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, La Laguna, 38206-Tenerife, Canary Islands, Spain. bmfraga@ipna.csic.es |
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| Abstract: | The microbiological transformation of dehydroabietanol (18-hydroxy-dehydroabietane) by Mucor plumbeus led to 2alpha,18-dihydroxy-abieta-8,11,13,15-tetraene, 2alpha,15-dihydroxy-dehydroabietanol, 2alpha-hydroxy-15-methoxy-dehydroabietanol, 7beta-hydroxy-2-oxo-dehydroabietanol, 15-hydroxy-2-oxo-dehydroabietanol and 15,16-dihydroxy-2-oxo-dehydroabietanol, whilst that of teideadiol (1alpha,18-dihydroxy-dehydroabietane) gave 2alpha-hydroxy-teideadiol, 7alpha-hydroxy-teideadiol and 7beta-hydroxy-teideadiol. Thus, 2alpha- and 7beta-hydroxylation occur in both biotransformations and the 15-hydroxylation is inhibited in the biotransformation of teideadiol by the presence of a 1alpha-alcohol. |
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| Keywords: | Mucor plumbeus Biotransformations Diterpenes Dehydroabietanol Teideadiol |
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