Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus |
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| Authors: | Kerns Robert J Rybak Michael J Kaatz Glenn W Vaka Flamur Cha Raymond Grucz Richard G Diwadkar Veena U Ward Tracey D |
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| Affiliation: | Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City 52242, USA. robert-kerns@uiowa.edu |
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| Abstract: | The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV. |
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