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Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp |
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| Authors: | Shao Chang-Lun Wang Chang-Yun Wei Mei-Yan Gu Yu-Cheng She Zhi-Gang Qian Pei-Yuan Lin Yong-Cheng |
| Affiliation: | a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People’s Republic of China b School of Pharmacy, Guangdong Medical College, Dongguan 523808, People’s Republic of China c Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom d School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People’s Republic of China e KAUST Global Academic Partnership Program, Section of Marine Ecology and Biotechnology, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, People’s Republic of China |
| Abstract: | Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. |
| Keywords: | Marine-derived fungus Aspergillus sp. Gorgonian Dichotella gemmacea Aspergilone X-ray analysis Cytotoxicity Antifouling activity |
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