Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis |
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| Authors: | Beaulieu Christian Wang Zhaoyin Denis Danielle Greig Gillian Lamontagne Sonia O'Neill Gary Slipetz Deborah Wang Jennifer |
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| Affiliation: | Merck Frosst Centre for Therapeutic Research, PO Box 1005, Kirkland, QC, Canada H9R 4P8. christian_beaulieu@merck.com |
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| Abstract: | ![]()
A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure-activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles. |
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