The role of vascular endothelial protein tyrosine phosphatase on nitric oxide synthase function in diabetes: from molecular biology to the clinic |
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| Authors: | Alberto Fernando Oliveira Justo Pedro Paulo Luciano Afonso |
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| Institution: | 1.Department of Medicine, Federal University of São Paulo - UNIFESP, São Paulo, São Paulo Brazil ;2.Hospital Municipal do Campo Limpo, São Paulo, São Paulo Brazil |
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| Abstract: | Endothelial nitric oxide synthase (eNOS) and receptor-type vascular endothelial protein tyrosine phosphatase (VE-PTP) are one of the majors signaling pathways related to endothelial health in diabetes. Several reports have shown that the inhibition of VE-PTP can lead the nitric oxide production, although repeated studies showed that VE-PTP regulated the eNOS exclusive at Ser1177 in indirect-manner. A recent, exciting paper (Siragusa et al. in Cardiovasc Res, 2020. https://doi.org/10.1093/cvr/cvaa213), showing that VE-PTP regulates eNOS in a direct-manner, dephosphorylating eNOS at Tyr81 and indirect at Ser1177 and the effects of a VE-PTP inhibitor, AKB-9778, in the blood pressure from diabetic patients. |
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| Keywords: | AKB-9778 VE-PTP eNOS eNOS tyrosine phosphorylation eNOS serine phosphorylation |
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