The involvement of central cholinergic mechanisms in cardiovascular responses to intracerebroventricular and intravenous administration of thyrotropin-releasing hormone |
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| Authors: | C Okuda T Mizobe M Miyazaki |
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| Affiliation: | 1. Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh;2. The Aristocrat Food Ltd., Dhaka 1212, Bangladesh;3. Akita Research Institute of Food and Brewing (ARIF), 4-26 Sanuki, Arayamachi, Akita 010-1623, Japan;4. Yamada Foods Co., Ltd., 279 Aza- kaidounoue, Noaramachi, Misato-cho, Akita 019-1301, Japan;5. Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, Japan;1. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;2. Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden;3. Department of Clinical Chemistry Sahlgrenska University Hospital, Gothenburg, Sweden;4. Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden;1. G. Oppenheimer Center for Neurobiology of Stress and Resilience, CURE: Digestive Diseases Research Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA;2. Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles, CA, USA;3. Sentia Medical Sciences, Inc., San Diego, CA, USA;4. Department of Medicine, Statistic Core, UCLA, Los Angeles, CA, USA |
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| Abstract: | Intracerebroventricular (i.c.v.) administration of thyrotropin-releasing hormone (TRH) in a range from 0.1 to 100 micrograms induced a dose-related increase in blood pressure in conscious rats, whereas TRH-free acid (TRH-OH) and histidyl-proline diketopiperazine (His-Pro-DKP), metabolites of TRH, did not. The blood pressure responses to intravenous (i.v.) injection of 5 mg/Kg TRH were similar to those induced by TRH (i.c.v.). Pretreatment with atropine (50 micrograms, i.c.v.) significantly reduced the pressor effect of TRH administered through either route. Hemicholinium-3 (50 micrograms, i.c.v.), an inhibitor of choline uptake, also prevented the increase in blood pressure induced by TRH (10 micrograms, i.c.v.). These results indicate that both centrally and peripherally administered TRH have pressor effects that are mediated by central cholinergic mechanisms, probably by activating cholinergic neurons. |
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