Neonatal hormonal influences on the development of proceptive and receptive feminine sexual behavior in rats |
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Authors: | Barbara H. Fadem Ronald J. Barfield |
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Affiliation: | Department of Biology, Livingston College, Rutgers University, New Brunswick, New Jersey 08903 U.S.A. |
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Abstract: | The objective of this study was to examine the influence of androgen and of the inhibiting of aromatization of androgen to estrogen during the early neonatal period on the development of receptive (lordosis and acceptance of stimulus male mounting attempts) and proceptive (affiliation with and solicitation of stimulus males) feminine sexual behavior. Within 8 hr of birth, male rats were castrated or received subcutaneous implants of the aromatase inhibitor androst-1,4,6-triene-3, 17-dione (ATD) while females received injections of testosterone propionate (TP). At 90 days of age all treated animals and controls were tested for receptive and proceptive feminine sexual behavior. It was found that androgen present neonatally blocked proceptive as well as receptive behavior patterns in adult rats. The proceptive and receptive feminine sexual behavior patterns displayed by adult males deprived of the effects of androgen neonatally either by castration or by treatment with ATD were comparable to those of normal females. |
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Keywords: | To whom correspondence should be addressed at: Department of Psychiatry and Mental Health Science MSB-E-521 College of Medicine and Dentistry of New Jersey New Jersey Medical School 100 Bergen Street Newark N.J. 07103. |
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