Trace Element Determination and Cardioprotection of <Emphasis Type="Italic">Terminalia pallida</Emphasis> Fruit Ethanolic Extract in Isoproterenol Induced Myocardial Infarcted Rats by ICP-MS |
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Authors: | Shaik Althaf Hussain Mohammed Abdul Kareem Shaik Nayab Rasool Suliman Yousef Al Omar Alwasel Saleh Manal Abdulrahman Al-Fwuaires Jayasimha Rayalu Daddam Kodidhela Lakshmi Devi |
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Institution: | 1.Central Laboratory, Department of Zoology, College of Science,King Saud University,Riyadh,Saudi Arabia;2.Department of Zoology, College of Science,King Saud University,Riyadh,Saudi Arabia;3.Department of Biochemistry,Indira Gandhi National Open University (IGNOU),New Delhi,India;4.Department of Biochemistry,National Post Graduate College,Nandyal,India;5.College of Science,King Faisal University,Hofuf,Saudi Arabia;6.Department of Zoology,Osmania University,Hyderabad,India;7.Department of Biochemistry,Sri Krishnadevaraya University,Anantapur,India |
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Abstract: | The trace elements and minerals in Terminalia pallida fruit ethanolic extract (TpFE) were determined by the instrument inductively coupled plasma-mass spectrometry (ICP-MS), and the cardioprotection of TpFE against isoproterenol (ISO)-administered rats was studied. Rats were pretreated with TpFE (100, 300, and 500 mg/kg bw) for 30 days, with concurrent administration of ISO (85 mg/kg bw) for two consecutive days. The levels of trace elements and minerals in TpFE were below the permitted limits of World Health Organization standards. ISO administration significantly increased the heart weight and cardiac marker enzymes in serum, xanthine oxidase, sodium, and calcium in the heart, whereas significantly decreased body weight, reduced glutathione, glutathione-S-transferase, superoxide dismutase, and potassium in the heart. Oral pretreatment of TpFE significantly prevented the ISO-induced alterations. This is the first report that revealed the determination of trace elements and mineral nutrients of TpFE by ICP-MS which plays a principal role in the herbal drug discovery for the treatment of cardiovascular diseases. |
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