Immediate effect of fluvastatin on lipid levels in acute coronary syndrome |
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Authors: | Petr Ostadal David Alan Jiri Vejvoda Jana Cepova Jiri Kukacka Peter Blasko Lucia Martinkovicova Jan Vojacek |
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Institution: | (1) Department of Cardiology, Charles University in Prague, 2nd Faculty of Medicine & University Hospital Motol, Prague, Czech Republic;(2) Cardiocenter, Department of Cardiology, Charles University in Prague, 3rd Faculty of Medicine & University Hospital Kralovske Vinohrady, Srobarova 50, Prague, 100 34, Czech Republic;(3) Department of Clinical Biochemistry and Pathobiochemistry, Charles University in Prague, 2nd Faculty of Medicine & University Hospital Motol, Prague, Czech Republic;(4) Department of Cardiac Surgery, Charles University in Prague, 2nd Faculty of Medicine & University Hospital Motol, Prague, Czech Republic |
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Abstract: | It is widely assumed that acute benefit of statin therapy is mediated especially by non-lipid effects. The immediate influence
of statins on lipid levels in patients with acute coronary syndrome (ACS) is, however, not clear. A total of 64 consecutive
patients with ACS were randomized at admission to fluvastatin 80 mg (Group 1, N = 32) or standard therapy without statin (Group 2, N = 32). The levels of total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol
(HDL-C), and triglycerides (TG) were examined at admission and after 24 h. Baseline characteristics were comparable in both
groups. In Group 1, fluvastatin significantly decreased the levels of TC by 14.5%, LDL-C by 17.2%, and HDL-C by 10.0% (P < 0.001); TG were not influenced. In Group 2 only marginal reductions in TC (by 4.1%, P = 0.03) and HDL-C (by 7.5%, P < 0.01) were detected; the levels of LDL-C and TG were not changed. As compared with Group 2, in Group 1 the final levels
of TC (P = 0.02) and LDL-C (P = 0.01) were significantly lower. Fluvastatin therapy, when started at admission in patients with ACS, significantly reduces
TC and LDL-C already after 24 h. We suggest that the lipid-lowering effect of statins in the therapy of ACS is probably as
prompt as non-lipid effects. |
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Keywords: | Fluvastatin Statin LDL-Cholesterol Cholesterol Acute Coronary Syndrome Myocardial Infarction Unstable Angina Pectoris |
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