| Geldanamycin induces CHOP expression through a 4-（2-aminoethyl）-benzenesulfonyl fluoride-responsive serine protease |
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| 作者姓名： | Hosoi T Hyoda K Okuma Y Nomura Y Ozawa K |
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| 作者单位： | [1]Department of Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiro- shima 734-8551, Japan [2]Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan [3]Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Sciences, Choshi, Chiba 288-0025, Japan [4]Yokohama College of Pharmacy, Yokohama, Kanagawa 245-0066, Japan |
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| 基金项目： | These two authors contributed equally to this work , Acknowledgments This research was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan, and by the Mochida Memorial Foundation for Medical and Pharmaceutical Research. |
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| 摘 要： | Dear Editor：
Geldanamycin is a benzoquinone ansamycin, which was originally described as a tyrosine kinase inhibitor. However, subsequent studies have revealed that geldanamycin binds to and inhibits heat-shock protein 90 （Hsp90） activity 1]. Hsp90 is a molecular chaperone involved in the conformational maturation of proteins such as mutated p53, Raf- 1, Akt, Bcr-Abl, and ErbB2. It is suggested that agents inhibiting Hsp90 have anti-cancer properties, although the precise molecular mechanisms underlying the anti-cancer effects of geldanamycin are not well understood.
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| 关 键 词： | 苯醌安莎霉素 诱导表达 CHOP 丝氨酸蛋白酶 热休克蛋白90 内质网 癌症 |
Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease |
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| Hosoi T,Hyoda K,Okuma Y,Nomura Y,Ozawa K.Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease[J].Cell Research,2007,17(2):184-186. |
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| Authors: | Hosoi Toru Hyoda Kanae Okuma Yasunobu Nomura Yasuyuki Ozawa Koichiro |
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