Ethanol directly increases dihydrotestosterone conversion primarily to 5 alpha-androstan-3 beta, 17 beta-diol in rat Leydig cells |
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Authors: | E P Murono V Fisher-Simpson |
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Institution: | Medical Research Service, Veterans Administration Hospital and Departmets of Medicine and Physiology, University of South Carolina School of Medicine, Columbia, South Carolina 20201, USA |
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Abstract: | Our studies demonstrate that direct stimulation of dihydrotestosterone metabolism by ethanol (2.2 - 65 mM) in rat Leydig cells primarily involves an increase in 5 alpha-androstan-3 beta, 17 beta-diol. Although the enzyme catalyzing this conversion, 5 alpha-androstane-3 beta-hydroxysteroid dehydrogenase, is localized in the microsomal fraction of Leydig cells, ethanol does not increase 5 alpha-androstan-3 beta, 17 beta-diol formation in isolated microsomes, presumably because of the removal of soluble alcohol dehydrogenase activity, which we propose mediates this action. Because 5 alpha-androstan-3 beta, 17 beta-diol is generally considered a weak or inactive androgen, this effect may function to decrease dihydrotestosterone secretion by Leydig cells and/or to reduce the availability of this androgen in responsive tissues. |
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Keywords: | For correspondence at the following address: Veterans Administration Hospital Dept of Medicine Bldg 28 Columbia SC 29201 USA |
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