Synthesis of constrained ceramide analogs and their potent antileukemic activities |
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| Authors: | Ha Hyun-Joon Hong Myeng Chan Ko Seung Whan Kim Yong Woo Lee Won Koo Park Jungchan |
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| Affiliation: | Department of Chemistry, Hankuk University of Foreign Studies, Yongin 449-791, Republic of Korea. hjha@hufs.ac.kr |
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| Abstract: | Constrained ceramide analogs were designed and synthesized by binding terminal alcohol and amine of ceramide with additional carbonyl functional group as 3-acetyl (3), 3-propionyl (4), 3-benzoyl (5), and 3-hexadecanoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin-2-ones (6). Compounds 4 and 5 showed potent antileukemic activities against human leukemia HL-60 cells with good correlation between cell death and DNA fragmentation. |
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