Chemopreventive effect of <Emphasis Type="BoldItalic">Padina boergesenii</Emphasis> extracts on ferric nitrilotriacetate (Fe-NTA)-induced oxidative damage in Wistar rats |
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| Authors: | Rajamani Karthikeyan T Manivasagam P Anantharaman T Balasubramanian S T Somasundaram |
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| Institution: | (1) CAS in Marine Biology, Annamalai University, Parangipettai, 608 502, India;(2) Department of Biochemistry & Biotechnology, Annamalai University, Annamalai Nagar, India;(3) CAS in Marine Biology, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India |
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| Abstract: | The present study was designed to investigate the prophylactic effect of extracts of the brown alga Padina boergesenii against potent nephrotoxic agent ferric nitrilotriacetate (Fe-NTA), in blood circulation of rats. Administration of Fe-NTA
for seven consecutive days significantly enhanced lipid peroxidation accompanied with reduction in glutathione content. Together
with this, the level of antioxidant enzymes, glutathione peroxidase, superoxide dismutase, and catalase was significantly
(P < 0.05) diminished. Pretreatment of rats with P. boergesenii (150 mg kg−1 body weight) reversed Fe-NTA-induced oxidative damage in lipid peroxidation and glutathione content significantly (P < 0.05). Further, the activity of antioxidant enzymes was also restored significantly. In order to assess the role of polyphenolic
components in the relevant activity, phenolic contents of the extract was found to be 1.78 ± 0.02% in the methanol extract
and 1.30 ± 0.30% in the diethyl ether extract. Hence, the present results confirm that the brown alga P. boergesenii preclude its role in Fe-NTA-induced oxidative damage and hyperproliferative response in circulation. |
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