Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs |
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Authors: | Helen E Gruber Jane A Ingram Gretchen L Hoelscher Natalia Zinchenko James H Norton Edward N Hanley Jr |
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Institution: | 1. Operative Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, via Cassia 600, 00189, Rome, Italy 2. Department of Internal Medicine, Regina Apostolorum Hospital, via San Francesco 50, 00041, Albano Laziale, Rome, Italy 3. Operative Unit of Rheumatology, San Filippo Neri Hospital, via Giovanni Martinotti 20, 00135, Rome, Italy 4. Department of Radiology, San Pietro Fatebenefratelli Hospital, via Cassia 600, 00189, Rome, Italy
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Abstract: | Introduction Comparison of intra-articular bacterial-derived hyaluronic acid (Hyalubrix®) (HA) with local analgesia (mepivacaine) for osteoarthritis (OA) of the hip. Methods A pilot prospective, double-blind, 6-month randomized trial of 42 patients with hip OA. HA or mepivacaine was administered twice (once a month) under ultrasound guidance. Efficacy measurements included the Lequesne's algofunctional index, a visual analog scale for pain, concomitant use of analgesia, patient and physician global measurement, and safety. Results Patients in the HA group exhibited a significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment (P < 0.001) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment (P < 0.05) compared with the local anesthetic group. All primary and secondary measures were significantly improved versus baseline, but other than the above were not different from each other at 3 or 6 months. Adverse effects were minimal. Conclusions This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA. Trial registration number ISRCTN39397064. |
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