Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests |
| |
Authors: | Piersma Aldert H Genschow Elke Verhoef Aart Spanjersberg Marielle Q I Brown Nigel A Brady Madeleine Burns Angie Clemann Nicole Seiler Andrea Spielmann Horst |
| |
Affiliation: | National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands. |
| |
Abstract: | A detailed report is presented on the performance of the postimplantation rat whole-embryo culture (WEC) test in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded test chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly embryotoxic on the basis of their in vivo effects in animals and/or humans, were tested in four laboratories. The outcome showed that the WEC test can be considered to be a scientifically validated test, which is ready for consideration for use in assessing the embryotoxic potentials of chemicals for regulatory purposes. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|