The Therapeutic Potential of Targeting Tumor Microenvironment in Breast Cancer: Rational Strategies and Recent Progress |
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| Authors: | Afsane Bahrami Seyed Mahdi Hassanian Majid Khazaei Malihe Hasanzadeh Soodabeh Shahidsales Mina Maftouh Gordon A. Ferns Amir Avan |
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| Affiliation: | 1. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Gynecology Oncology, Woman Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;7. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;8. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK |
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| Abstract: | The tumor microenvironment (TME) is cellular environment in addition to harboring carcinoma cells, consists of different components (e.g., blood vessels, immune cells, fibroblasts, bone marrow‐derived inflammatory cells, lymphocytes, signaling molecules, and the extracellular matrix) that have an essential role on drug activity and efficacy. There is growing body of evidence showing its involvement in the progression and metastasis of different cancers, including breast cancer (BC). These observations provide a proof of concept of targeting TME compartments as a novel potential therapeutic approach in treatment of this malignancy, which is the main interested for current review. J. Cell. Biochem. 119: 111–122, 2018. © 2017 Wiley Periodicals, Inc. |
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| Keywords: | BREAST CANCER TUMOR MICROENVIRONMENT SRTOMA FIBROBLAST MACROPHAGE |
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