Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1‐(2‐aminoethyl)pyrrolidine,diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity |
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| Authors: | Esra Dilek Sema Caglar Kübra Erdogan Bülent Caglar Onur Sahin |
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| Affiliation: | 1. Faculty of Pharmacy, Department of Biochemistry, Erzincan University, Erzincan, Turkey;2. Faculty of Sciences and Arts, Department of Chemistry, Erzincan University, Erzincan, Turkey;3. Institute of Science and Technology, Department of Chemistry, Erzincan University, Erzincan, Turkey;4. Scientific and Technological Research Application and Research Center, Sinop University, Sinop, Turkey |
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| Abstract: | In this study, the effects of four novel mononuclear palladium(II) and platinum(II) complexes on the activity of human serum paraoxanase1 were examined. First, four novel mononuclear palladium(II) and platinum(II) complexes were synthesized with a nitrogen donor ligand 1‐(2‐aminoethyl)pyrrolidine and nonsteroidal anti‐inflammatory drugs diclofenac, mefenamic acid. These complexes were characterized by spectroscopic, thermal, and elemental analyses. The crystal structures of complex [Pd(2‐amepyr)2](dicl)2 1 and [Pd(2‐amepyr)2](mef)2 3 were determined by X‐ray crystallography. Then, paraoxonase1 enzyme was purified from human serum. The effects of these complexes on enzyme were evaluated in vitro. The complexes consist of the cationic unit and the counterions. The diclofenac and mefenamic acid acted as a counterion in the complexes. It was observed that all the complexes were stable up to high temperatures. These complexes, even at low doses, inhibited the activity of the enzyme with different inhibition mechanisms. |
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| Keywords: | crystal structure enzyme inhibition palladium(II) and platinum(II) complexes paraoxonase1 |
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