Prophylactic administration of carnosine and melatonin abates the incidence of renal toxicity induced by an over dose of titanium dioxide nanoparticles |
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| Authors: | Laila Mohamed Fadda Azza M Mohamed Hanaa Mahmoud Ali Hanan Hagar Manal Aldossari |
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| Institution: | 1. Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia;2. Biochemistry Department, Faculty of Science‐Al Faisaliah, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia;3. Therapeutic Chemistry Department, National Research Center, Dokki, Egypt;4. Genetic and Cytology Department, National Research Center, Dokki, Egypt;5. Common First Year Deanship, King Saud University, Riyadh, Kingdom of Saudi Arabia;6. Pharmacology Unit (31), Medical College and King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia;7. Master degree student at Pharmacology Department;8. Faculty of Pharmacy, King Saud University, Riyadh, KSA |
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| Abstract: | The alleviative effects of two antioxidants, carnosine (Car) and melatonin (Mel), against titanium dioxide nanoparticles (TiO2‐NPs) toxicity‐induced oxidative and inflammatory renal damage were examined in rats. Administration of these antioxidants along with TiO2‐NPs effectively reduced serum urea, uric acid, creatinine, glucose, tumor necrosis factor‐α, interleukin‐6, C‐reactive protein, immunoglobulin G, vascular endothelial growth factor, and nitric oxide, as well as a significant amelioration of the decrease in glutathione levels in renal tissue was observed, compared to those in rats treated with TiO2‐NPs alone. The renoprotective properties of the antioxidants were confirmed by reduced intensity of renal damage as demonstrated by histological findings. In conclusion, Car and Mel play protective roles against TiO2‐NPs‐induced renal inflammation and oxidative injury, likely due to their antioxidant and anti‐inflammatory properties. |
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| Keywords: | carnosine creatinine GSH melatonin VEGF |
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