Antioxidant,anti‐inflammatory,and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives |
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Authors: | Shivraj Hariram Nile Young Soo Keum Arti Shivraj Nile Shivkumar S Jalde Rahul V Patel |
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Institution: | 1. Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul 143701, Republic of Korea;2. Department of Crop Science, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea;3. DongSung Pharmaceuticals, Dong‐gu Daegu, Republic of Korea;4. Department of Food Science and Biotechnology, Dongguk University, Ilsandong‐gu, Goyang‐si, Republic of Korea |
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Abstract: | The synthesized flavonoid derivatives were examined for their antioxidant, anti‐inflammatory, xanthine oxidase (XO), urease inhibitory activity, and cytotoxicity. Except few, all the flavonoids under this study showed significant antioxidant activity (45.6%–85.5%, 32.6%–70.6%, and 24.9%–65.5% inhibition by DPPH, ferric reducing/antioxidant power, and oxygen radical absorption capacity assays) with promising TNF‐α inhibitory activity (42%–73% at 10 μM) and IL‐6 inhibitory activity (54%–81% at 10 μM) compared with that of control dexamethasone. The flavonoids luteolin, apigenin, diosmetin, chrysin, O3?, O7‐dihexyl diosmetin, O4?, O7‐dihexyl apigenin, and O7‐hexyl chrysin, showed an inhibition with IC50 values (4.5‐8.1 μg/mL), more than allopurinol (8.5 μg/mL) at 5 μM against XO and showing more than 50% inhibition at a final concentration (5 mM) with an IC50 value of ranging from 4.8 to 7.2 (μg/mL) in comparison with the positive control thiourea (5.8 μg/mL) for urease inhibition. Thus, the flavonoid derivatives may be considered as potential antioxidant and antigout agents. |
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Keywords: | antioxidant flavonoids inhibition urease xanthine oxidase |
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