Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity

Rutin, naturally occurring flavonoid, has reported to cover interesting multiple pharmacological properties. This study evaluated rutin or/and meloxicam effects in paw inflammation induced by formalin in mice. Mice were divided into four groups: I‐Formalin group, II‐Rutin 60 mg/kg (p.o.), III‐Meloxicam 10 mg/kg (p.o.), plus IV‐Combined rutin and meloxicam. Therapies were administered once a day for 7 days. The curative effects were assessed on inflammatory, oxidative stress, and apoptosis. Both rutin and/or meloxicam induced marked improvement in paw licking time on the 1st day and by combined treatment only on the 3rd day as well reduction in paw edema% on the 3rd day. Moreover, noticeable progress in liver malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities as well decline in paw interleukin‐1β level and extent of apoptosis. The results spot light on the good influence of combined rutin and meloxicam in formalin‐induced mice paw inflammation to a better extent than either rutin or meloxicam lonely.