The presence of Na+ channels in myometrial smooth muscle cells is revealed by specific neurotoxins |
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| Authors: | T Amédée J F Renaud K Jmari A Lombet J Mironneau M Lazdunski |
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| Affiliation: | 1. Institut de Biochimie Cellulaire et Neurochimie du CNRS, Université de Bordeaux II, 1 rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France;2. Centre de Biochimie du CNRS, Parc Valrose, 06034 Nice Cedex, France;1. Department of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA;2. Department of Neuroscience, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA;1. Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada;2. Department of Physiology, University of Toronto, M5S 1A1, Canada;3. Department of Obstetrics & Gynecology, University of Toronto, M5S 1A1, Canada;1. Department of Obstetrics and Gynecology, Washington University in St. Louis, School of Medicine, St Louis, MO, United States;2. Department of Neuroscience, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States |
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| Abstract: | This paper shows the presence, in rat myometrial smooth muscles, of low affinity binding sites for tetrodotoxin with a K0.5 value of 2 microM. Electrophysiological experiments using both intact strips and single isolated myometrial cells in culture have shown that veratridine and sea anemone toxins reveal functional Na+ channels. The activity of these channels was blocked by tetrodotoxin (10 microM) or by removal of Na+ ions. Results presented here are the first direct demonstration of the existence in rat myometrium of Na+ channels of the tetrodotoxin-resistant type. |
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