Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes |
| |
Authors: | Gabi Kastenmüller Elisabeth Maria Schenk Johann Gasteiger Hans-Werner Mewes |
| |
Institution: | Gabi Kastenmüller, Maria Elisabeth Schenk, Johann Gasteiger, and Hans-Werner Mewes |
| |
Abstract: | Identifying the biochemical basis of microbial phenotypes is a main objective of comparative genomics. Here we present a novel method using multivariate machine learning techniques for comparing automatically derived metabolic reconstructions of sequenced genomes on a large scale. Applying our method to 266 genomes directly led to testable hypotheses such as the link between the potential of microorganisms to cause periodontal disease and their ability to degrade histidine, a link also supported by clinical studies. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |