Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis |
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Authors: | M Corbel C Belleguic E Boichot V Lagente |
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Institution: | INSERM U456, IFR 97, Université de Rennes I, France. |
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Abstract: | Pulmonary fibrosis has an aggressive course and is usually fatal an average of 3 to 6 years after the onset of symptoms. Pulmonary
fibrosis is associated with deposition of extracellular matrix (ECM) components in the lung interstitium. Matrix metalloproteinases
(MMPs) are a major group of proteinases known to regulate the ECM remodeling and so they are hypothesized to be important
in the process of lung fibrosis. These led to the concept that modulation of airway remodeling including excessive proteolytic
damage of the tissue may be of interest for future treatment. The excessive airway remodeling as a result of an imbalance
in the equilibrium of the normal processes of synthesis and degradation of extracellular matrix components could argue in
favor of antiprotease treatments. Moreover, these observations emphasize that effective therapies for these disorders must
be given early in the natural history of the disease, prior to the development of expensive lung destruction and fibrosis.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | fibrosis inflammation lung matrix metalloproteinase TIMP |
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