Rat atrial natriuretic factor suppresses proopiomelanocortin-derived peptides secretion from both anterior and intermediate lobe cells and growth hormone release from anterior lobe cells of rat pituitary in vitro |
| |
| Authors: | T Shibasaki M Naruse N Yamauchi A Masuda T Imaki K Naruse H Demura N Ling T Inagami K Shizume |
| |
| Affiliation: | 1. Oregon State University, College of Earth, Ocean and Atmospheric Sciences, 104 Ocean Admin. Bldg., Corvallis, OR 97331, USA;2. Camosun College, Department of Chemistry and Geoscience, Lansdowne Campus, 3100 Foul Bay Rd., Victoria, British Columbia V8P 5J2, Canada;3. Instituto Andaluz de Ciencias de la Tierra, Av. de las Palmeras, 418100 Granada, Spain;1. Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA |
| |
| Abstract: | Synthetic rat atrial natriuretic factor (ANF) was found to attenuate, in a dose-dependent manner, basal and corticotropin-releasing factor-induced secretion of proopiomelanocortin-derived peptides from cultured anterior and intermediate lobe cells of rat pituitary. ANF was also found to suppress basal and growth hormone-releasing factor-stimulated secretion of growth hormone from anterior lobe cells of rat pituitary. These results, together with reports of the existence of ANF-positive neurons in the hypothalamus and ANF-positive fibers in the median eminence, suggest that hypothalamic ANF is probably involved in the regulation of pituitary hormone secretion, especially that of proopiomelanocortin-derived peptides and growth hormone. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
