Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress |
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| Authors: | Zhang Hui Zhao Yang Tian Tian Paton Adrienne W Paton James C Kitamura Masanori |
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| Affiliation: | aDepartment of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan;bDepartment of Nephrology, First Affiliated Hospital of China Medical University, Shenyang 110001, China;cResearch Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia |
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| Abstract: | Periodic patterns of biochemical systems determine the function, behavior, and fate of eukaryotic cells. The cascades of mitogen-activated protein (MAP) kinases play crucial roles in a diverse range of cell function, and recent reports indicate that oscillation of extracellular signal-regulated kinase (ERK) activity is observed following stimulation by some growth factors. In the current report, we provide evidence that ERK and c-Jun N-terminal kinase, but not p38 MAP kinase, are activated periodically in response to endoplasmic reticulum stress. When activity of MAP kinases is evaluated, their oscillatory property should be considered carefully, especially under stress conditions. |
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| Keywords: | MAP kinase ERK JNK Subtilase cytotoxin ER stress Oscillation |
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