Attenuation of endothelium-dependent relaxation in mesenteric artery during noise-induced hypertension |
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Authors: | C C Wu S J Chen M H Yen |
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Institution: | (1) Department of Pharmacology, National Defense Medical Center, PO Box 90048-504, 100 Taipei, Taiwan (ROC) |
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Abstract: | The present study was designed to determine whether there is a causal relationship between noise-induced hypertension and changes of endothelial function. Rats were exposed to noise stress (100 dB, 1 kHz, 4 h/day, 6 days/week) for 1–4 weeks. The systolic blood pressure was significantly increased after rats were exposed to noise stress for 3 weeks. The relaxant responses of isolated mesenteric arterial rings to endothelium-dependent vasodilators (A23187 and acetylcholine) in noise-treated rats were significantly less than those in control rats. This difference in response to acetylcholine still existed in the presence of methylene blue or N -nitro-L-arginine. On the other hand, the responses to the endothelium-independent vasodilator nitroglycerin were not affected in rats exposed to noise stress. The attenuation to endothelium-dependent vasodilators during noise stress may result in increasing peripheral vascular resistance and thus elevate blood pressure. This indicates that noise-induced hypertension may be partly due to the alterations of endothelial activity. |
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Keywords: | Noise Endothelium A23187 Acetylcholine Nitroglycerin |
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