Adenovirus vaccine strains genetically engineered to express HIV-1 or HBV antigens for use as live recombinant vaccines |
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| Authors: | P P Hung P K Chanda R J Natuk B B Mason M Chengalvala B M Bhat K L Molnar-Kimber S K Dheer J E Morin S Mizutani |
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| Institution: | Wyeth-Ayerst Research, Philadelphia, Pa. |
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| Abstract: | Types 4 and 7 adenovirus are currently used as live, oral vaccines for the prevention of adenovirus respiratory disease in military recruits. These vaccine strains have been genetically engineered in order to express HIV-1 or HBV antigens in infected cells. A dog model was developed to evaluate the immunogenicity of these recombinant vaccines. Dogs inoculated with live adenovirus-HBV recombinant vaccine produced antibody against hepatitis B surface antigen. |
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