New Resorcinol Derivatives from a Sponge‐Derived Fungus Hansfordia sinuosae |
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| Authors: | Zehong Wu Yuan Li Dong Liu Min Ma Jianliang Chen Wenhan Lin |
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| Affiliation: | 1. The Eighth Affiliated Hospital, Sun Yat‐sen University, Shenzhen, P. R. China;2. Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, P. R. China;3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P. R. China |
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| Abstract: | Ten new resorcinol derivatives named hansfordiols A – J ( 1 – 10 ) were isolated from the fermentation broth of the sponge‐derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT‐IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher's method and their specific optical rotation. The structures of compounds 8 – 10 were featured with various chlorination at aromatic rings. Their antioxidant activities on ABTS, cytotoxicity on the HCT‐8, Bel‐7402, BGC‐823, A549, and A2780 cell lines, and antibacterial activities were evaluated. |
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| Keywords: | Resorcinol derivative
Hansfordia sinuosae
Antioxidant activities Cytotoxic activities Antibacterial activities |
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