An Unusual Tetrahydrofuran Lignan from the Roots of Zanthoxylum planispinum and the Potential Anti‐inflammatory Effects |
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| Authors: | Guang‐Yao Su Yu‐Chun Cheng Kui‐Wu Wang Xiang‐Yang Wang Bin Wu |
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| Institution: | 1. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, P. R. China;2. Library, Zhejiang University of Finance & Economics, Hangzhou, P. R. China;3. Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Hangzhou, P. R. China;4. Ocean College, Zhejiang University, Hangzhou, P. R. China |
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| Abstract: | An unusual tetrahydrofuran lignin, zanthplanispine ( 1 ), together with 14 known lignans ( 2 – 15 ) were isolated from the AcOEt‐soluble fraction from the MeOH extract of Z. planispinum roots. The structures of 1 was elucidated on the basis of 1D‐ and 2D‐NMR experiments as well as HR‐ESI‐MS analysis. The known compounds were identified by the comparison of their NMR data with previously reported in the literatures. Bioassay showed that compounds 1 – 4 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW 264.7 cells. In particular, compound 1 showed significant inhibitory activity with an IC50 value of 36.8 μm . |
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| Keywords: |
Zanthoxylum planispinum
Tetrahydrofuran lignan Anti‐inflammatory activity Zanthplanispine |
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