Four New Nanaomycins Produced by Streptomyces hebeiensis Derived from Lichen |
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| Authors: | Chengbin Liu Yi Jiang Hui Lei Xiu Chen Qingjuan Ma Li Han Xueshi Huang |
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| Affiliation: | 1. Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China;2. Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, P. R. China |
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| Abstract: | Four new nanaomycins ( 1 – 4 ), together with two known compounds, nanaomycin αA ( 5 ) and nanaomycin βA ( 6 ) were isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen. The structures of the new nanaomycins 1 – 4 were established using comprehensive NMR spectroscopic data analysis as well as UV, IR, and MS data. The antimicrobial activities of 1 – 6 were evaluated against Gram‐positive bacteria and fungus. Compounds 5 and 6 showed antimicrobial activities against the test microorganisms, while 1 – 4 were inactive at 100 μg/ml. |
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| Keywords: | Antimicrobial activity Nanaomycin Lichen
Streptomyces hebeiensis
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