Cytotoxic and Anti‐inflammatory Sesquiterpenes from Ainsliaea henryi |
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| Authors: | Ren‐Tao Zeng Xue‐Yun Dong Xing Fang Niao Yang Zhi‐Ran Shi Zhi‐Guo Zhuo Yun‐Heng Shen Wei‐Dong Zhang |
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| Institution: | 1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China;2. School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, P. R. China;3. Shanghai Institute of Pharmaceutical Industry, Shanghai, P. R. China |
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| Abstract: | Three new sesquiterpenoids, 4α‐hydroxyeudesm‐11(13)‐en‐12‐yl 3‐methylbutanoate ( 1 ), diaspanolide E ( 2 ), and (13α)‐germacra‐1(10),4‐dien‐12,8α‐olid‐15‐oic acid ( 3 ), along with eight known sesquiterpenoids ( 4 – 11 ), were isolated from the aerial parts of Ainsliaea henryi. The chemical structures of compounds 1 – 3 were elucidated by spectroscopic analysis (1D‐, 2D‐NMR, MS and HR/MS). All isolates were evaluated for their inhibitory activities against nitric oxide (NO) production in lipopolysaccharide‐induced RAW264.7 macrophage cells. Compound 10 exhibited significantly inhibition against NO release with an IC50 value of 6.54 ± 0.16 μm . Also, all isolated compounds were tested for cytotoxicity against three human tumor cell lines A549, MGC803, and HCT116, among which compound 5 significantly inhibited the proliferation of MGC803 cell lines with an IC50 value of 2.2 ± 0.2 μm . |
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| Keywords: | Ainsliaea species Ainsliaea henryi Sesquiterpenoids NO production Cytotoxic activities |
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