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Four New Diterpene Glucosides from Perovskia atriplicifolia
Authors:Lu Gao  Jun Zhou  Le‐Yu Zhu  Juan‐Rong Zhang  Yu‐Xing Jing  Jia‐Wen Zhao  Xiang‐Zhong Huang  Gan‐Peng Li  Zhi‐Yong Jiang  Da‐Yuan Xue
Affiliation:1. College of Life & Environmental Sciences, Minzu University of China, Beijing, P. R. China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
Abstract:Four new diterpene glucosides, namely perovskiaditerpenosides A – D ( 1  –  4 ), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.
Keywords:Labiatae     Perovskia atriplicifolia     Diterpene glucosides  Perovskiaditerpenosides A        D  Cytotoxic activities
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