Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells |
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| Authors: | Joon Young Bae Jin Woo Lee Qinghao Jin Hari Jang Dongho Lee Youngsoo Kim Jin Tae Hong Mi Kyeong Lee Moon Soon Lee Bang Yeon Hwang |
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| Affiliation: | 1. College of Pharmacy, Chungbuk National University, Cheongju, Korea;2. College of Life Sciences and Biotechnology, Korea University, Seoul, Korea;3. College of Agriculture, Life and Environmental Sciences, Chungbuk National University, Cheongju, Korea |
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| Abstract: | Bioassay‐guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C‐methylated flavan‐3‐ols, bletillanols A ( 1 ) and B ( 2 ), along with ten known compounds ( 3 – 12 ). Their structures were determined by using extensive spectroscopic analysis including 1D‐, 2D‐NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS‐stimulated RAW 264.7 cells. |
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| Keywords: |
Bletilla striata
Orchidaceae Flavan‐3‐ol Nitric oxide production Bletillanol A Bletillanol B |
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