Studies on mammalian chromosome replication : III. Organization and replication of diplochromosomes |
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| Authors: | Yun-Fai Lau |
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| Affiliation: | Department of Medicine and the Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA |
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| Abstract: | The process of DNA synthesis in normal and endoreduplicating mammalian cells are very similar. Both types of chromosomes are replicated in defined units termed chromosomal replicons, and in the same sequences along their lengths. The sister chromosomes of the diplochromosomes are replicated synchronously in identical patterns. The present observations suggest that organization and sequences of chromosome replication are genetically programmed. |
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