Osteoprotegerin,RANK, RANKL |
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Authors: | Stejskal D Bartek J Pastorková R Růzicka V Oral I Horalík D |
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Affiliation: | Department of Laboratory Medicine and Internal Medicine, Hospital Sternberk. |
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Abstract: | Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism. RANKL may promote osteoresorption by induction of cathepsin K gene expression. The present paper summarizes the most significant data in osteoprotegerin, RANK and RANKL problems obtained. |
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