| TLR4在哺乳动物对脂多糖反应中的作用 |
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| 引用本文： | 龚小卫,姜勇.TLR4在哺乳动物对脂多糖反应中的作用[J].生物化学与生物物理进展,2001,28(3):299-303. |
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| 作者姓名： | 龚小卫 姜勇 |
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| 作者单位： | 第一军医大学 |
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| 基金项目： | 国家杰出青年科学基金（39925014）、国家自然科学基金重点项目（39830400）和军队杰出人才基金（98J003）资助项目. |
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| 摘 要： | Toll信号转导通路在果蝇的发育和天然免疫反应中起重要作用.最近在小鼠进行的定点克隆研究表明Lps位座编码一种Toll样受体TLR4，该受体作为LPS受体复合物的跨膜成分而转导脂多糖(LPS)信号，而其相关蛋白TLR2则在其他病原体微生物介导的细胞反应中起作用.TLR4的发现使我们对LPS信号转导通路的认识前进了一大步.
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| 关 键 词： | Toll样受体4，脂多糖，信号转导 |
| 收稿时间： | 6/5/2000 12:00:00 AM |
| 修稿时间： | 7/7/2000 12:00:00 AM |
The Role of TLR4 in Response to LPS in Mammals |
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| GONG Xiao-Wei and JIANG Yong.The Role of TLR4 in Response to LPS in Mammals[J].Progress In Biochemistry and Biophysics,2001,28(3):299-303. |
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| Authors: | GONG Xiao-Wei and JIANG Yong |
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| Institution: | Department of Pathophysiology and Key Laboratory for Shock and Microcirculation of PLA, The First Military Medical University, Guangzhou 510515, China;Department of Pathophysiology and Key Laboratory for Shock and Microcirculation of PLA, The First Military Medical University, Guangzhou 510515, China |
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| Abstract: | Toll signal transduction pathway plays a critical role in development as well as in innate immune responses in Drosophila. Positional cloning work proceeded in mice recently has revealed that Lps encodes the Toll-like receptor 4 (TLR4) of mammals, which functions as the transmembrane component of LPS receptor complex. In contrast, TLR2, a receptor closely related to TLR4, makes no contribution to LPS induced signaling. The discovery of TLR4 has greatly promoted understanding on the LPS signal transduction pathway. |
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| Keywords: | Toll-like receptor 4 lipopolysaccharide signal transduction |
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