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Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications |
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| Authors: | Laure Gabison Thierry Prangé Nathalie Colloc'h Mohamed El Hajji Bertrand Castro Mohamed Chiadmi |
| Affiliation: | 1.LCRB, UMR CNRS 8015, Université Paris Descartes,Paris cedex 06,France;2.CI-NAPS, UMR 6232, UCBN, CNRS, centre CYCERON, Boulevard Becquerel,Caen cedex,France;3.SANOFI-AVENTIS Recherche & Développement,Montpellier,France |
| Abstract: | BackgroundUrate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces. |
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