An electron microscopic,enzyme cytochemical study on the localization of lactate dehydrogenase (LDH) in osteoclasts and peritoneal macrophages of the rat and its implication for the process of bone resorption and the origin of osteoclasts |
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| Authors: | Dr J J A Touw A M Hemrika-Wagner J P W Vermeiden |
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| Institution: | (1) Department of Orthodontics, School of Dentistry, Vrije Universiteit, Amsterdam, The Netherlands;(2) Department of Orthodontics, School of Dentistry, Vrije Universiteit, P.O. Box 7161, 1007 Amsterdam, The Netherlands |
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| Abstract: | Summary LDH is localized along various intracytoplasmatic membranes of osteoclasts. Macrophages show membrane-bound LDH only after phagocytosis of calcium hydroxylapatite, the main mineral constituent of bone. The localization of LDH in these macrophages is almost the same as in osteoclasts. The significance of this finding, and its possible implication in the process of bone resorption and the origin of osteoclasts are discussed.
Present Adress: Department of Oral Microbiology, School of Dentistry, Vrije Universiteit, P.O. Box 7161, 1007 MC Amsterdam, The Netherlands |
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| Keywords: | Osteoclast Macrophage LDH Bone resorption |
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