A conserved family of doublesex-related genes from fishes |
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| Authors: | Huang Xiao Cheng Hanhua Guo Yiqing Liu Li Gui Jianfang Zhou Rongjia |
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| Institution: | Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, P. R. China. |
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| Abstract: | The sex-determining gene Mab-3 of C. elegans and the doublesex gene of Drosophila each contain a common DM domain and share a similar role. Human doublesex-related gene DMRT1 also encodes a conserved DM-related DNA-binding domain. We present here the amplification of a broad range of DM domain sequences from three fish species using degenerate PCR. Our results reveal unexpected complexity of the DM domain gene family in vertebrates. |
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