An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines |
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Authors: | Parmar Narsidas J Pansuriya Bhavesh R Barad Hitesh A Kant Rajni Gupta Vivek K |
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Affiliation: | Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Dist. Anand, Gujarat, India. njpchemdeptspu@yahoo.co.in |
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Abstract: | An improved microwave assisted one-pot method for the synthesis of twelve new aryldiazenylchromeno [4,3-b] pyrrolidines via intramolecular azomethine ylide cycloaddition route is described. The method is efficient and advantageous over conventional and solvent-free thermal methods. The stereochemistry of the compounds was confirmed on the basis of various NMR experiments, and finally by single crystal X-ray diffraction data. N-Methyl or ethyl pyrrolidine based heterocycles gave good biological activities. |
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