Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds |
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| Authors: | Sashidhara Koneni V Kumar Abdhesh Dodda Ranga Prasad Krishna Naikade Niraj Agarwal Pooja Srivastava Kumkum Puri S K |
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| Affiliation: | Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226 001, India. sashidhar123@gmail.com |
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| Abstract: | First synthesis of novel coumarin-trioxane hybrids is reported. The synthesis was achieved via condensation of β-hydroxyhydroperoxides with coumarinic-aldehydes in presence of p-toluenesulfonic acid in good yields and the novel hybrids were evaluated for their antimalarial activity both in vitro and in vivo. |
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