| 毛果鱼藤化学成分及生物活性研究 |
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| 引用本文： | 蓝俊杰,张华,娄华勇,吴红果,潘卫东. 毛果鱼藤化学成分及生物活性研究[J]. 热带亚热带植物学报, 2016, 24(4): 471-476 |
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| 作者姓名： | 蓝俊杰 张华 娄华勇 吴红果 潘卫东 |
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| 作者单位： | 1. 贵州大学药学院, 贵阳 550002; 2. 贵州省中国科学院天然产物化学重点实验室, 贵阳 550002,国药一心制药有限公司, 长春 130012,贵州省中国科学院天然产物化学重点实验室, 贵阳 550002,贵州省中国科学院天然产物化学重点实验室, 贵阳 550002,贵州省中国科学院天然产物化学重点实验室, 贵阳 550002 |
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| 基金项目： | 国家自然科学基金项目（81160390）；贵州省科技创新人才团队项目（[2015]4026）；贵州省科技联合基金项目（[2015]7400）资助 |
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| 摘 要： | 为了解毛果鱼藤(Derris eriocarpa How)藤茎和根中的生物活性成分,采用柱色谱技术,从其乙酸乙酯萃取部位分离得到6个化合物,分别鉴定为:高丽槐素(1)、美迪紫檀素(2)、大黄素(3)、松脂醇(4)、(6R,9R)9-hydroxy-4-megastigmen-3-one(5)、2-methoxygliricidol(6)。这些化合物均为首次从该植物中分离得到。体外抑菌、细胞毒抑制活性测试结果表明,化合物1、2对部分肿瘤细胞株及结核分枝杆菌(H37Rv)有明显抑制活性。
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| 关 键 词： | 毛果鱼藤 化学成分 结构 筛选 |
| 收稿时间： | 2015-11-09 |
| 修稿时间： | 2016-01-19 |
Chemical Costituents and Bioactivities from Derris eriocarpa How |
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| LAN Jun-jie,ZHANG Hu,LOU Hua-yong,WU Hong-guo and PAN Wei-dong. Chemical Costituents and Bioactivities from Derris eriocarpa How[J]. Journal of Tropical and Subtropical Botany, 2016, 24(4): 471-476 |
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| Authors: | LAN Jun-jie ZHANG Hu LOU Hua-yong WU Hong-guo PAN Wei-dong |
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| Affiliation: | 1. College of Pharmacy Guizhou University, Guiyang 550002, China; 2. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Science, Guiyang 550002, China,Sinopharm A-Think Pharmaceuticals Co., Ltd., Changchun 130012, China,Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Science, Guiyang 550002, China,Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Science, Guiyang 550002, China and Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Science, Guiyang 550002, China |
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| Abstract: | In order to understand the bioactivity constituents form Derris eriocarpa How, six compounds were isolated from ethyl acetate fraction of ethanol extract of its stems and roots by using chromatographic techniques. On the basis of spectral data, their structures were identified as (-)-maackiain (1), medicarpin (2), emodin (3), (-)-pinoresinol (4), (6R,9R)9-hydroxy-4-megastigmen-3-one (5), 2-methoxygliricidol (6). All these compounds were isolated from this species for the first time. Furthermore, compounds 1 and 2 exhibited significantly inhibitory activities in vitro against some of tumor cell lines and mycobacterium tuberculosis (H37Rv). |
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| Keywords: | Derris eriocarpa Chemical constituent Structure Screen |
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