Production and metabolic engineering of bioactive substances in plant hairy root culture |
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| Authors: | Mei-Liang Zhou Xue-Mei Zhu Ji-Rong Shao Yi-Xiong Tang Yan-Min Wu |
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| Affiliation: | (1) School of Life Science, Sichuan Agricultural University, Yaan, Sichuan, 625014, People’s Republic of China;(2) Room 211, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Zhongguancun south street No 12, Haidian district, Beijing, 100081, People’s Republic of China;(3) Plant Cell Physiology, Institute of Biology, Sylvius Laboratory, Leiden University, Sylviusweg 72, P.O. Box 9505, 2300 RA Leiden, The Netherlands;(4) School of Resources and Environment, Sichuan Agricultural University, Yaan, Sichuan, 625014, People’s Republic of China; |
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| Abstract: | In the past three decades, hairy roots research for the production of valuable biological active substances has received a lot of attention. The addition of knowledge to enhance the yields of desired substances and the development of novel tools for biomass engineering offer new possibilities for large-scale cultivation of the plant hairy root. Hairy roots can also produce recombinant proteins through the transfer of Agrobacterium T-DNA into the plant genome, and thereby hold immense potential for the pharmaceutical industry. This review highlights some of the significant progress made in the past few years and outlines future prospects for exploiting the potential utility of hairy root cultures as “chemical factories” for producing bioactive substances. |
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