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Estimating the number of coding mutations in genotypic and phenotypic driven <Emphasis Type="Italic">N</Emphasis>-ethyl-<Emphasis Type="Italic">N</Emphasis>-nitrosourea (ENU) screens: revisited
Authors:David A Keays  Taane G Clark  Thomas G Campbell  John Broxholme  William Valdar
Institution:(1) Psychiatric Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom
Abstract:We recently described methods for estimating the number of N-ethyl-N-nitrosourea (ENU)-induced coding mutations in phenotypic and genotypic screens. In this article we revisit these methods, clarifying their application. In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations ().
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