F(1)F(0) ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane |
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| Authors: | van Bloois Edwin Jan Haan Gert de Gier Jan-Willem Oudega Bauke Luirink Joen |
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| Institution: | Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands. |
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| Abstract: | Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane integration. We have examined the biogenesis of the F1F0 ATP synthase subunit c, a small double spanning IMP, using complementary in vivo and in vitro approaches. The data suggest that F0c is targeted by the SRP to the membrane, where it inserts at YidC in a Sec-independent mechanism. F0c appears to be the first natural substrate of this novel pathway. |
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