Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice |
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Authors: | Beamer Gillian L Flaherty David K Assogba Barnabe D Stromberg Paul Gonzalez-Juarrero Mercedes de Waal Malefyt Rene Vesosky Bridget Turner Joanne |
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Institution: | Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA. |
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Abstract: | IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune responses. The immunological consequences of IL-10 production during pulmonary tuberculosis (TB) are currently unknown, although IL-10 has been implicated in reactivation TB in humans and with TB disease in mice. Using Mycobacterium tuberculosis-susceptible CBA/J mice, we show that blocking the action of IL-10 in vivo during chronic infection stabilized the pulmonary bacterial load and improved survival. Furthermore, this beneficial outcome was highly associated with the recruitment of T cells to the lungs and enhanced T cell IFN-gamma production. Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans. |
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