Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone,metabolites of catecholamine and cortisol in healthy volunteers |
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Authors: | Dominika Kanikowska Junichi Sugenoya Maki Sato Yuuki Shimizu Yoko Inukai Naoki Nishimura Satoshi Iwase |
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Institution: | (1) Department of Physiology, Aichi Medical University School of Medicine, Nagakute Aichi, 480-1195, Japan;(2) Department of Biology and Environmental Studies, University of Medical Sciences, Poznan, Poland |
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Abstract: | We investigated seasonal changes in blood concentrations of interleukin-6 (IL-6), adrenocorticotrophic hormone (ACTH), metabolites
of catecholamine (VMA, HVA, and 5-HIAA) and cortisol in humans. Eight volunteers were investigated at four times during the
year (February, May, August and October) at latitude 35° N. The mean ambient temperature at the collection periods was higher
in the order of summer > autumn ≈ spring > winter. Changes in mood were also monitored by a profile of mood states (POMS)
questionnaire. The concentration of IL-6 was significantly higher in winter and summer than in spring and autumn. The concentrations
of ACTH, HVA and VMA were significantly higher in summer. No seasonal variation was detected in cortisol. There were significant
differences among the seasons in subscale tension and anger in the POMS questionnaire; the tension subscale showed significant
differences between spring and autumn, with a higher score in spring. The results demonstrate that Il-6, ACTH, HVA and VMA
exhibit statistically significant seasonal rhythms, which might have important diagnostic and therapeutic implications. |
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