Dietary flaxseed reduces Myocardial Ischemic Lesions,improves cardiac function and lowers cholesterol levels despite the presence of severe obesity in JCR:LA-cp Rats |
| |
| Institution: | 1. Department of Physiology and Pathophysiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba''s, Canada;2. Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic;3. Metabolic and Cardiovascular Diseases Laboratory, Division of Human Nutrition, University of Alberta, Edmonton, Alberta, Canada;4. Canadian Centre for Agri-food Research in Health and Medicine (CCARM), 351 Taché Avenue, Winnipeg, Manitoba''s, Canada;5. The Institute of Cardiovascular Sciences, 351 Taché Avenue, Winnipeg, Manitoba''s, Canada;6. Agriculture and Agri-Food Canada, St. Boniface Hospital Albrechtsen Research Centre, 351 Taché Avenue, Winnipeg, Manitoba''s, Canada;1. Department of Nutrition, China Medical University, Taichung, Taiwan;2. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan;3. Department of Cardiology, China Medical University Hospital, Taichung, Taiwan;4. Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan;5. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan;6. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan;1. Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina,;2. Department of Biochemistry & Molecular Biology, Hollings Cancer center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina,;3. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, |
| |
| Abstract: | Previous work has shown that dietary flaxseed can significantly reduce cardiac damage from a coronary artery ligation-induced myocardial infarction. However, this model uses healthy animals and the ligation creates the infarct in an artificial manner. The purpose of this study was to determine if dietary flaxseed can protect the hearts of JCR:LA-cp rats, a model of genetic obesity and metabolic syndrome, from naturally occurring myocardial ischemic lesions. Male and female obese rats were randomized into four groups (n = 8 each) to receive, for 12 weeks, either a) control diet (Con), b) control diet supplemented with 10% ground flaxseed (CFlax), c) a high-fat, high sucrose (HFHS) diet, or d) HFHS supplemented with 10% ground flaxseed (HFlax). Male and female JCR:LA-cp lean rats served as genetic controls and received similar dietary interventions. In male obese rats, serum total cholesterol and LDL-C were significantly lower in CFlax compared to Con. Obese rats on HFHS exhibited increased myocardial ischemic lesions and diastolic dysfunction regardless of sex. HFlax significantly lowered the frequency of cardiac lesions and improved diastolic function in male and female obese rats compared to HFHS. Blood pressures were similar in obese and lean rats. No aortic atherosclerotic lesions were detectable in any group. Collectively, this study shows that a HFHS diet increased myocardial ischemic lesion frequency and abolished the protective effect of female sex on cardiac function. More importantly, the data demonstrates dietary flaxseed protected against the development of small spontaneous cardiac infarcts despite the ingestion of a HFHS diet and the presence of morbid obesity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
