Plasma levels of trace element status in early pregnancy and the risk of gestational diabetes mellitus: A nested case-control study |
| |
| Affiliation: | 1. College of Health Science and Nursing, Wuhan Polytechnic University, Wuhan, 430023, Hubei, China;2. Department of Epidemiology, Brown School of Public Health, Providence, RI, USA;3. Department of Biostatistics, Brown School of Public Health, Providence, RI, USA;4. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Rd, NE, Atlanta, GA, 30322, USA;5. Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China;1. Center for Advanced Studies and Technology (C.A.S.T.), “G. d''Annunzio” University of Chieti-Pescara, Via Luigi Polacchi 11, Chieti, I-66100, Italy;2. Department of Physics, Università Degli Studi di Milano, Via Celoria 16, Milano, I-20133, Italy;3. LASA, Department of Physics, Università Degli Studi di Milano and INFN-Milano, Via F.lli Cervi 201, Segrate, MI, I-20090, Italy;4. Institute of Clinical Immunotherapy and Advanced Biological Treatments, Piazza Pierangeli 1, Pescara, Italy;5. Rectorate of Leonardo da Vinci Telematic University, Largo San Rocco 11 Torrevecchia, Teatina, CH, Italy;6. Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, via Luigi Polacchi 11, Chieti, I-66100, Italy;1. Univ. Grenoble Alpes, CEA, IRIG, 38000, Grenoble, France;2. Univ. Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and Environmental and System Biology (BEeSy), 38000, Grenoble, France;1. Department of Physiology, School of Sport Sciences, University of Extremadura, Avenida de la Universidad s/n, 10003 Cáceres, Extremadura, Spain;2. Department of Sport Science, Faculty of Education, Pontifical University of Salamanca, C/Henry Collet, 52–70, CP: 37007 Salamanca, Spain;3. Movement, Brain and Health (MOBhe) Research Group, Center of Higher Education Alberta Giménez, affiliated to Comillas Pontifical University, Costa de Saragossa 16, 07013 Palma, Mallorca, Balearic Islands, Spain;4. Faculty of Language and Education, University of Nebrija, Campus La Berzosa, Calle del Hostal, 28248, Hoyo de Manzanares, Madrid, Spain;1. Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, 511443, China;2. Department of Information, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China;3. Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511443, China;1. Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;2. The Eighth People’s Hospital of Jinan, Jinan, Shandong, China;3. Department of Group Health, Maternal and Child Health Institution, Kunshan, Jiangsu, China;4. Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, China;5. Department of Clinical Laboratory, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, No.189, Chaoyang Road, 215300, Jiangsu, China;1. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland;2. Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology of Polish Academy of Sciences, Postępu 36A Jastrzębiec, 05-552 Magdalenka, Poland;3. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland |
| |
| Abstract: | PurposeWe investigated the impacts of plasma levels of magnesium (Mg), zinc (Zn), calcium (Ca), iron (Fe), copper (Cu), selenium (Se), and chromium (Cr) on GDM risk and the potential mediation effect of blood glucose levels on the relationship between trace elements and GDM risk.MethodsThis nested case-control study was based on data from a birth cohort study conducted in Wuhan, China in 2013−2016. A total of 305 GDM cases and 305 individually-matched controls were included in the study. Conditional logistic regression models were used to estimate the associations between plasma trace element concentrations and GDM risk. A mediation analysis was conducted to explore whether blood glucose levels act as a mediator between trace element levels and GDM risk.ResultsAn IQR increment in plasma levels of Fe and Cu was associated with a significant increase in GDM risk [OR = 2.04 (95 % CI 1.62, 2.57) and OR = 1.52 (95 % CI 1.25, 1.82)], respectively. On the other hand, an IQR increment in plasma levels of Zn and Ca was associated with a significant decrease in GDM risk [OR = 0.55 (95 % CI 0.43, 0.71) and OR = 0.72 (95 % CI 0.56, 0.92)], respectively. The mediation analysis showed significant mediation of the association between Cu and GDM risk via the FBG (%mediated: 19.27 %), 1 h-PBG (12.64 %), 2h-PBG (28.44 %) pathways.ConclusionsPlasma levels of Zn and Ca were negatively associated with GDM risk, while Fe and Cu were positively associated. Blood glucose levels act as a mediator between plasma trace element exposures and GDM risk. |
| |
| Keywords: | Blood glucose Gestational diabetes mellitus Trace elements |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
