Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport |
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| Institution: | 1. Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, UK;2. The Kavli Institute for Nanoscience Discovery, 3 South Parks Road, Oxford, OX1 3QU, UK;1. Department of Biochemistry, University of Oxford, Oxford, United Kingdom;2. Chemistry Research laboratory, University of Oxford, Oxford, United Kingdom;1. Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK;1. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA;2. Department of Physics, University of Arizona, Tucson, AZ 85721, USA;3. Bio 5 Institute, University of Arizona, Tucson, AZ 85721, USA |
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| Abstract: | Membrane proteins are important macromolecules that play crucial roles in many cellular and physiological processes. Over the past two decades, the use of mass spectrometry as a biophysical tool to characterise membrane proteins has grown steadily. By capturing these dynamic complexes in the gas phase, many unknown small molecule interactions have been revealed. One particular application of this research has been the focus on antibiotic resistance with considerable efforts being made to understand underlying mechanisms. Here we review recent advances in the application of mass spectrometry that have yielded both structural and dynamic information on the interactions of antibiotics with proteins involved in bacterial cell envelope biogenesis and drug efflux. |
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